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Microscopic worms could provide key to repairing injured nerves

A severed nerve cell – microscopic roundworm species C. elegans can mend severed nerve cells through a process called axonal fusion.

Microscopic worms could provide key to repairing injured nerves

A tiny worm’s ability to repair damaged nerves could one day help people with nerve injuries such as paralysis, according to University of Queensland research.

A team led by Professor Massimo Hilliard, Dr Rosina Giordano-Santini and Dr Casey Linton from UQ’s Queensland Brain Institute and Dr Brent Neumann from Monash University has discovered key information on how the microscopic roundworm species C. elegans spontaneously reconnects severed nerves.

Professor Hilliard said rejoining nerves could be a treatment for people with nervous system injuries, which often cause life-long disabilities.

“Nerves communicate using lengthy rope-like structures called axons and we’d already discovered that roundworms can reconnect two separated axons in a process called axonal fusion,” he said.

“We knew that a molecule called EFF-1 kicked off this fusion process, but now have discovered that the protein RAB-5 controls the level of the molecule.

“When RAB-5 is lacking, there is more EFF-1 present and axons fuse better.”

Dr Giordano-Santini said any application to humans was still a long way off, but manipulating the activity of RAB-5 in roundworms had provided a means to promote efficient neuron repair, a method that could be replicated in humans.

“EFF-1 isn’t present in humans but RAB-5 is, and we do produce several proteins that promote the fusion of membranes,” she said.

“Very little is known about how these proteins are regulated, but they may function in a similar way to EFF-1.

If this is the case, RAB-5 could play a role in their regulation, making it a target for controlling nerve repair in mammals.

“This could ultimately deliver a future where we have the ability to promote the fusion of damaged nerves in humans to restore their function.”

The research has been published in Journal of Neuroscience and was supported by organisations including the National Health and Medical Research Council of Australia, the Australian Research Council and the Human Frontier Science Program.

source: The University of Queensland

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