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‘Old’ sperm produces healthier offspring

‘Old’ sperm produces healthier offspring

Sperm that live for longer before fertilising an egg produce healthier offspring – according to new research from Uppsala University and University of East Anglia, Great Britain.

New research published today shows that longer-lived sperm in an ejaculate of a zebrafish male produce offspring with longer and healthier lifespans – who in turn produce more and healthier offspring themselves – than the shorter-lived sperm in the same ejaculate.

The findings may have important implications for human reproduction and fertility, particularly in the context of assisted fertilisation technologies.

Lead researcher Dr Simone Immler, from UEA’s School of Biological Sciences and previously Uppsala University , said: “One male produces thousands to millions of sperm in a single ejaculate but only very few end up fertilizing an egg.

“The sperm within an ejaculate vary not only in their shape and performance, but also in the genetic material that each of them carries. Until now, there was a general assumption that it doesn’t really matter which sperm fertilises an egg as long as it can fertilise it. But we have shown that there are massive differences between sperm and how they affect the offspring.”

The research team performed in vitro fertilisations by collecting gametes from males and females. They then split the ejaculate of a male into two halves.

In one half, they selected for shorter-lived sperm and in the other for longer lived sperm. They then added the sperm to two half clutches from a female to fertilise the eggs and reared the offspring into adulthood.

They then monitored their lifespan and their reproductive output for two years.

Dr Immler said: “We found that when we select for the longer-lived sperm within the ejaculate of male zebrafish, the resulting offspring is much fitter than their full siblings sired by the shorter-lived sperm of the same male.

“More specifically, offspring sired by longer-lived sperm produce more and healthier offspring throughout their life that age at a slower rate.This is a surprising result, which suggests that it is important to understand how sperm selection may contribute to the fitness of the next generations.”

The researchers are currently in the process of identifying the genes underlying their findings.

“This research has important implications for evolutionary biology and potentially beyond into areas that use assisted fertilization technologies, for example in livestock rearing or IVF in humans,” added Dr Immler.

The research was funded by the European Research Council.

source: Uppsala University – Uppsala, Sweden

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