Structure of Botox, left, and Tetanus toxin
Modified Botox Could be New Treatment for Chronic Pain, Epilepsy
By using neurotoxins produced by bacteria of the genus Clostridium (C. botulinum and C. tetani), commonly known as Botox and Tetanus toxin respectively, a large group of scientists has created and characterized a new molecule that could be used to treat neurological disorders.
While the Botox element is able to block neuronal communication – and therefore pain signals – for months, the Tetanus component targets the central nervous system very effectively.
The combination of the two elements is of great interest for neuroscience and can be applied to the treatment of several neurological disorders, particularly chronic pain conditions and epilepsy.
Botox and Tetanus neurotoxins hold great promise for clinical applications, but their paralytic activity was a stumbling block until now.
The scientists demonstrated that the newly engineered molecule is a potent non-paralyzing neuronal blocker.