Home / Science / Medical / New tools to combat kidney fibrosis

New tools to combat kidney fibrosis

 

New tools to combat kidney fibrosis

by Leigh MacMillan

Interstitial fibrosis – excessive tissue scarring – contributes to chronic kidney disease, which is increasing in prevalence in the United States.

Raymond Harris, M.D., and colleagues have previously implicated the epidermal growth factor receptor (EGFR) in the pathogenesis of diabetic nephropathy and kidney fibrosis, but the role of sustained EGFR activation in the renal tubule (a specific region of the kidney) is unknown.

The investigators have now developed a mouse model of persistent EGFR activation in epithelial cells of the renal proximal tubule.

They demonstrated that the mice develop spontaneous, progressive tubulointerstitial fibrosis, characterized by epithelial cell dedifferentiation (loss of “mature” identity), increased numbers of myofibroblasts and immune cells, and increased matrix deposition. Genetic or pharmacologic inhibition of EGFR activity reduced fibrosis.

The study, reported in the October issue of The FASEB Journal, shows that sustained EGFR activation in the kidney causes kidney fibrosis. The mouse model provides a platform to identify novel targets and treatment strategies to combat fibrosis.

This research was supported by grants from the National Institutes of Health (DK051265, DK095785, DK103067, DK007569) and by a Veterans Affairs Merit Award.

source: Vanderbilt University – Nashville, Tennessee

Telegram Channel

About Mohammad Daeizadeh

  • تمامی فایل ها قبل از قرار گیری در سایت تست شده اند.لطفا در صورت بروز هرگونه مشکل از طریق نظرات مارا مطلع سازید.
  • پسورد تمامی فایل های موجود در سایت www.parsseh.com می باشد.(تمامی حروف را می بایست کوچک وارد کنید)
  • Password = www.parsseh.com

Leave a Reply

Your email address will not be published. Required fields are marked *

*