Home / Science / Medical / Restricting HIV-1 infection

Restricting HIV-1 infection

 

 

Restricting HIV-1 infection

by Leigh MacMillan

The HIV-1 capsid protein (CA) interacts with viral factors that support infection and host factors that restrict it. The host protein cyclophilin A (CypA) binds to CA and enhances the action of host restriction factors that block HIV-1 infection.

Christopher Aiken, Ph.D., and colleagues investigated how CypA potentiates the action of the restriction factor TRIM5alpha in African green monkey cells. They did not find evidence of a role for CypA in promoting binding of TRIM5alpha to the viral capsid or inhibiting reverse transcription of the viral genome.

Instead, the investigators observed a CypA-dependent reduction in the accumulation of nuclear HIV-1 DNA, suggesting that CypA promotes TRIM5alpha inhibition of HIV-1 nuclear import. They reported their findings in the journal PLOS ONE.

The authors propose that CypA uses a common mechanism involving interactions of the virus with nuclear pore components to potentiate restriction of HIV-1 infection by TRIM5alpha and other capsid-targeting inhibitors.

This research was supported by the National Institutes of Health grant AI076121.

source: Vanderbilt University · Nashville, Tennessee

Telegram Channel

About Mohammad Daeizadeh

  • تمامی فایل ها قبل از قرار گیری در سایت تست شده اند.لطفا در صورت بروز هرگونه مشکل از طریق نظرات مارا مطلع سازید.
  • پسورد تمامی فایل های موجود در سایت www.parsseh.com می باشد.(تمامی حروف را می بایست کوچک وارد کنید)
  • Password = www.parsseh.com

Leave a Reply

Your email address will not be published. Required fields are marked *

*