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Online Tool Predicts Heart Disease Events in Young Adults


Online Tool Predicts Heart Disease Events in Young Adults

By Anna Williams

An online calculator using lifestyle metrics showed initial success at predicting the risk of heart disease events among young, healthy adults, according to a new study published in JAMA Internal Medicine.

Donald Lloyd-Jones, MD, ScM, senior associate dean for clinical and translational research and chair of Preventive Medicine, was a senior author of the study.

Donald Lloyd-Jones, MD, ScM, senior associate dean for clinical and translational research and chair of Preventive Medicine, was a senior author of the study.


The Healthy Heart Score (HHS), a free, web-sited tool developed by Harvard investigators, allows individuals to assess their risk of heart disease by answering simple questions about nine key lifestyle factors, such as weight, smoking habits, exercise and diet.

The tool was developed for and validated in middle-age and older adults, however, and had never been assessed in young, healthy adults — a group that could potentially benefit most from early prevention measures.

“We were very interested in understanding how lifestyle — and this particular score that encompasses healthy lifestyles — might be useful in younger people to help us predict whether there might be the onset of early heart attacks and strokes,” said Lloyd-Jones, also director of the Northwestern University Clinical and Translational Sciences Institute (NUCATS) and a professor of Medicine in the Division of Cardiology.

In the study, the team of investigators used data from healthy adults 18 to 30 years old who had been included in the Coronary Artery Risk Development in Young Adults (CARDIA) study to calculate the Healthy Heart Score of each individual.

They discovered that overall, HHS performed moderately well at estimating the 25-year risk for premature cardiovascular events — such as heart attack and stroke — in this group of young, healthy adults. In particular, the tool was most accurate when performed in men, white participants and those who did not have any heart disease risk factors — such as diabetes or hypertension — at baseline.

The hope is that the HHS might now serve as a valuable tool for young adults to gauge their risk of heart disease and if necessary, make appropriate changes.

“This is a tool that physicians and a patient could use together, or a patient on their own, to understand what about their lifestyle is contributing to some risk,” Lloyd-Jones said. “That should then hopefully start a conversation about what might be successful strategies to improve their lifestyle now to help avoid some of these later complications.”

Lloyd-Jones, also the Eileen M. Foell Professor of Heart Research, added that the personalized, interactive nature of the HHS might make it particularly impactful.

“With the score, you get a more personalized sense of what your risk is — rather than just generic advice about eating well and moving more,” he said. “This helps to make more concrete the risk that is associated with these health behaviors, and hopefully helps to spur the behavior change that we’re looking to see in our patients.”

In future research, the investigators plan to assess whether there might be a critical time period when it is most crucial to rectify health behaviors, as well as examine how to best implement the Healthy Heart Score in clinical practice.

The study was also co-authored by Norrina Allen, PhD, MPH, assistant professor of Preventive Medicine in the Division of Epidemiology and Hongyan Ning, MD, MS, statistical analyst in the Department of Preventive Medicine.

The research was supported by award K23HL122361-01A1 from the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH); by the NHLBI in collaboration with awards HHSN268201300025C and HHSN268201300026C from the University of Alabama at Birmingham, award HHSN268201300027C from Northwestern University, award HHSN268201300028C from the University of Minnesota, award HHSN268201300029C from the Kaiser Foundation Research Institute, and award HHSN268200900041C from Johns Hopkins University School of Medicine (Coronary Artery Risk Development in Young Adults [CARDIA] study); and by the Intramural Research Program of the National Institute on Aging (NIA) and intra-agency agreement AG0005 between the NIA and NHLBI (CARDIA study).

source: Northwestern University

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