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Free download of : ENZYMES-A Practical Introduction to Structure, Mechanism, and Data Analysis-Robert A. Copeland

ENZYMES-A Practical Introduction to Structure, Mechanism, and Data Analysis-Robert A. Copeland

 

Free download of : ENZYMES-A Practical Introduction to Structure, Mechanism, and Data Analysis-Robert A. Copeland

The latter half of this century has seen an unprecedented expansion in our knowledge and use of enzymes in a broad range of basic research and industrial applications. Enzymes are the catalytic cornerstones of metabolism, and as such are the focus of intense research within the biomedical community. Indeed enzymes remain the most common targets for therapeutic intervention within the pharmaceutical industry. Since ancient times enzymes also have played central roles in many manufacturing processes, such as in the production of wine, cheese, and breads. During the 1970s and 1980s much of the focus of the biochemical community shifted to the cloning and expression of proteins
through the methods of molecular biology. Recently, some attention has shifted back to physicochemical characterization of these proteins, and their interactions with other macromolecules and small molecular weight ligands (e.g., substrates, activators, and inhibitors). Hence, there has been a resurgence of interest in the study of enzyme structures, kinetics, and mechanisms of catalysis. ………

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