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Virus Gene Syncytin Insinuated Itself in Mammalian DNA Millions of Years Ago

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Virus Gene Syncytin Insinuated Itself in Mammalian DNA Millions of Years Ago

Syncytin is a gene that was found in the human genome, but is bears all of the hallmarks of originating from a virus. Back in 2000, a team of Bostonian scientists discovered it. The cells of syncytin were located only where the placenta made contact with the uterus. They fused together to form a single cellular layer, which is called the syncytiotrophoblast, essential for a fetus to draw nutrients from its mother.

In order to fuse, the cells must make syncytin. Viruses insinuated themselves into the genome of our ancestors millions of years ago, by infecting eggs or sperm and inserting their own DNA into ours. There are 100,000 known virus fragments in the human genome, making up about 8% of our DNA. Most of this DNA has been mutated so much that it’s been rendered ineffective, yet there are still some viral genes that make up proteins in our bodies.

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Syncytin isn’t unique to humans. Other mammals, like chimpanzees, gorillas, and monkeys have it. The gene is similar in each of these species, including humans. Syncytin 2 was discovered, and it helps tamp down a mother’s immune system so that it doesn’t attack the baby as a foreign tissue.

In 2005, syncytin was discovered in mice, but it’s different from the one found in primates. Since then, it’s also been discovered in rabbits. The latest version has been discovered in dogs, cats, pandas, hyenas and other mammals that belong to the taxonomic order Carnivora.

After the ancestors of Carnivora split from mammals, about 85 million years ago, they also got infected with a virus, which is called syncytin-Car-1. On at least 6 different occasions, viruses have gotten snagged into mammalian hosts and have carried out the same function: building placentas. Pigs and horses don’t have this open layer in their placenta, which could imply that they’ve never gotten sick with the right virus.

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